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It’s a good time to be a mouse.
I really hope we push to get to the point of using grown / harvesting tissue of organ donors to keep alive in environments which we can test stuff on.
There’s a real moral dilemma of making a mini human brain and then testing all sorts of meds on it.
But man, mice just aren’t the best analog. They do have obvious pros of being cheap, having short life cycles, and having a massive body of testing to compare. But they don’t always translate well to humans. I’m worried we’re missing out on stuff that works on us and not on them.
Take too much and you start to remember the future.
The article mentions an existing drug than "inhibits PNNs" that they plan to test. Anyone know what that might be?
**EDIT**: Seems like this same, or a very similar, "discovery" was made years ago. One drug mentioned was: Protease-free chABC from Proteus vulgaris from Amsbio: https://www.jneurosci.org/content/37/5/1269
The religious profess that anything is possible through god, whereas those of us in science know that anything is possible in mice.
They can do everything in mice now; whether the results are replicable in humans is another matter entirely.
Recursion by Blake Crouch